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OneAndOneIs2

Thu, Feb 21, 2008

[Link][Icon]Genetic engineering - indirectly

The modern world is full of contradictions. As previously-fatal diseases such as diabetes becomes easily treatable, there is no longer any 'selection pressure' removing carriers of genetic susceptibility to diseases from the gene pool.

The upshot of this is that the diseases will increase in number. Great for the people who manufacture the cure, but less great for the population as a whole. By finding a treatment for a condition, you actually make it afflict more people.

A possible solution is to use genetic engineering to remove 'faulty' genes so that inherited disorders are not passed on. But there are so many issues that arise when you start thinking about tampering with human genes.

So what about an alternative way of using GE to improve human health?

As we all know, the typical western diet is far too high in carbohydrates, particularly sugars; and fats, particularly saturated fats.

So here's an idea. We've all seen "friendly bacteria" yoghurt advertised - at least, I have, and with the miniscule amount of TV I watch, if I've seen it the whole world has.

What if you were to GE these bacteria to be even more friendly?

It doesn't actually matter how much sugar you eat. Seriously, it doesn't. What matters is how much gets through your gut and into the bloodstream.

So if you had a whole load of bacteria that got there first...

Some bacteria can polymerise sugars into cellulose - which we can't digest. If the bacteria in our stomachs could be engineered to "soak up" the excess sugar and convert it in this manner, they would eliminate one of the big excesses from our diet, and also provide us with both extra fiber, and water - both of which we could mostly do with more of.

And if those bacteria used the cellulose to put a wall around themselves, like plant cells do, and then absorbed all the fat they could find.. well, then all that sugary fatty food would be turned into millions of tiny balls of indigestible, fat-filled grains of fiber.

Sure, it wouldn't solve every problem. But if bacteria COULD be engineered to do this, it could stop an awful lot of diet-related health problems at a stroke.

No pun intended ;o)

7 comments • Categories: Omni, Health, Technology

Comments:

Comment from: ginny [Member] Email · http://iamgenevieve.wordpress.com/
This isn't related really to your post, but...

I love all the names they have on those "friendly bacteria" yoghurt drinks.

"L.casei Imunitass" and "Bifidus ActiRegularis" are on their websites, and there's also "Bifidus Digestivum" (Sp?) and all sorts of other, really stupid ones...

PermalinkPermalink 21/02/08 @ 22:12
Comment from: hari [Member] Email · http://hari.literaryforums.org
Bacteria or virus, that is the question...
PermalinkPermalink 22/02/08 @ 08:11
Comment from: alison [Member] · http://www.creativehedghog.com
Bacteria- self contained cell. Virus- uses other cells (your's!) to reproduce.

I like this idea Dom. Doctors here in Bolivia prescribe friendly bacteria (a powder you mix up and drink) for tummy troubles now- even instead of antibiotics! Biogurt, here I come!
PermalinkPermalink 22/02/08 @ 10:48
Comment from: oneandoneis2 [Member] · http://geekblog.oneandoneis2.org/
Possibly you meant bacteria or fungi, Hari..?

I had heard of bacteria for upset stomachs. I gather that these days you can even get them to reduce your chances of an upset if you go to another country and drink the water. Amazing stuff!
PermalinkPermalink 22/02/08 @ 12:57
Comment from: hari [Member] Email · http://hari.literaryforums.org
Actually I was just being tongue-in-cheek there...
PermalinkPermalink 23/02/08 @ 04:18
Comment from: WillieWonka [Visitor] Email
Step 2: we'd need to engineer a set of bacteria for the lower intestine that convert a percentage of the cellulose back to sugar, one to convert the fat to certain compositions, and a few to produce theobromine and trace chemicals.

Then we'd all poop chocolate.
PermalinkPermalink 27/02/08 @ 21:18
Comment from: Anderlan [Visitor] Email · http://gnuber.com/
I have a solution. Eat less refined sugar. Ta- frickin-dA!

Seriously, having had a small diverticulitis episode and being only 34 I have new respect for the intricacies of the functions of the gut. It's too easy for me to just fix my diet for me to consider introducing GE bugs into my gut ecology. How bout I just ingest a pill with the appropriate enzymes from said bacteria?

That's what it seems like is a strategic decision in things like energy production and other industrial chemical processes. Do we use a vat of bacteria to work on things directly or do we take the enzymes from said vat of bacteria and apply them directly?

It's quite amazing what they can find in bugs. You can find 100,000 different species in a few cubic inches of soil. It seems like the soil may be a better life matrix than seawater. Aubrey Grey presented to Google about removing detrimental fatty deposits from vessel walls. He told about how it seems we can find bacteria which have ordinarily infinitesimal ecological niches where they are capable of ingesting any particular type C-H chain that would ever exist. E.G., there are small numbers of bugs which come out of the woodwork in soil on the side of the road, capable of digesting tire rubber.
PermalinkPermalink 21/03/08 @ 15:00

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